Bromocriptine Capsules and Sandostatin LAR Depot

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Octreotide may increase the blood levels and effects of bromocriptine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with somatostatin analogs may increase the plasma concentrations of bromocriptine. The mechanism may involve inhibition of CYP450 3A4 metabolism secondary to suppression of growth hormones by somatostatin analogs. In a study of 12 patients with active acromegaly, the bioavailability of bromocriptine was increased by approximately 40% during coadministration with octreotide relative to administration alone. No data are available for lanreotide or pasireotide, although a similar interaction is theoretically possible.

MANAGEMENT: Caution is advised when bromocriptine is prescribed in combination with somatostatin analogs. Monitoring for increased adverse effects is recommended, including: nausea; vomiting; dizziness; hypotension; somnolence or sudden sleep onset, particularly in patients with Parkinson's disease; and cold-sensitive digital vasospasm in acromegalic patients.

Bromocriptine Capsules

Generic Name: bromocriptine

Brand name: Parlodel, Cycloset

Synonyms: Bromocriptine

What is Bromocriptine Capsules?

Sandostatin LAR Depot

Generic Name: octreotide

Brand name: Sandostatin, Sandostatin LAR Depot

Synonyms: Sandostatin LAR Depot (injection)

What is Sandostatin LAR Depot?