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Bromocriptine (Cycloset) and Neoral

Determining the interaction of Bromocriptine (Cycloset) and Neoral and the possibility of their joint administration.

Check result:
Bromocriptine (Cycloset) <> Neoral
Relevance: 10.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using bromocriptine together with cycloSPORINE can increase the levels of cycloSPORINE. Tell your doctor if you experience dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. Talk with your doctor if you develop fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Bromocriptine may increase cyclosporine concentrations. The proposed mechanism is inhibition of CYP450 3A4 metabolism. Serum cyclosporine concentrations and risk of toxicity may be increased.

MANAGEMENT: If concomitant therapy is necessary, serum cyclosporine levels and renal function should be closely monitored. Dosage adjustments may be required. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, fatigue, headache, or other unusual symptoms.

References
  • "Product Information. Neoral Soft Gelatin Capsules (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Bromocriptine (Cycloset)

Generic Name: bromocriptine

Brand name: Parlodel, Cycloset

Synonyms: Bromocriptine

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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