Brotapp and Reserpine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using reserpine together with pseudoephedrine may alter the effects of both medications. Specifically, pseudoephedrine can reduce the effects of reserpine in treating high blood pressure, while its own effects may be increased or decreased. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Sympathomimetic amines may decrease the hypotensive effect of postganglionic adrenergic blocking agents, while the latter may potentiate the pharmacologic effects of direct-acting sympathomimetic amines (e.g., dobutamine, epinephrine, methoxamine, norepinephrine) but inhibit those that are primarily indirect-acting (e.g., mephentermine). Postganglionic adrenergic blocking agents such as guanadrel, guanethidine, and rauwolfia alkaloids work by depleting catecholamine stores from adrenergic nerve endings. Therefore, they may sensitize adrenergic receptors to direct-acting sympathomimetics, but blunt the effects of indirect-acting agents whose activity is mediated through the release of catecholamines. Guanethidine and reserpine have been reported to attenuate the pharmacologic effects (mydriasis, pressor response) induced by ephedrine and dopamine, both of which exhibit direct and indirect sympathomimetic activities (i.e., mixed-acting). However, guanethidine intensified the mydriasis produced by phenylephrine, which is also thought to be mixed-acting. Conversely, ephedrine has been shown to partially reverse the hypotensive effect of guanethidine.

MANAGEMENT: Due to their pressor effect, sympathomimetic amines should be used cautiously in patients with hypertension. Alternatives to postganglionic adrenergic blocking agents should be considered if patients are treated with sympathomimetic amines, since effects of the latter may be intensified or diminished depending on whether they are direct- or indirect-acting. Most agents with indirect sympathomimetic activity are mixed-acting, thus it may be difficult to predict how they will be affected by postganglionic adrenergic blocking agents. If the combination is used, blood pressure and heart rate should be monitored.

Brotapp

Generic Name: brompheniramine / pseudoephedrine

Brand name: Bromaline, Brotapp, J-TanD PD, Lodrane D, Q-Tapp, Endafed, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Bromfed PD, Dallergy JR, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Bromfed, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Bromfenex, Lodrane Liquid, Nalfed, Rondec Chewable, Touro Allergy, Rondec Syrup, Bromfed SR, Histex SR, Rondec, Andehist NR Syrup, Dimetapp Elixir, Bromaxefed RF Syrup, Brofed, Sildec, Bromhist Pediatric Drops, Lodrane 12D, AccuHist Pediatric, AccuHist Drops, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Bidhist-D, Dimaphen, Brovex SR, Lodrane 24D, LoHist-PD, LoHist-12D, B-Vex PD, BroveX PSE, BroveX PD, BroveX PSB, LoHist PSB

Synonyms: n.a.

What is Brotapp?

Reserpine

Generic Name: reserpine

Brand name:

Synonyms: n.a.

What is Reserpine?