Drug search by name

Budeprion SR and Ticlopidine

Determining the interaction of Budeprion SR and Ticlopidine and the possibility of their joint administration.

Check result:

Budeprion SR <> Ticlopidine

Relevance: 24.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ticlopidine may increase the blood levels and effects of buPROPion. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience seizures, anxiety, tremor, insomnia, hallucinations, confusion, and/or difficulty concentrating, as these may be signs and symptoms of excessive buPROPion levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ticlopidine may increase the plasma concentrations of bupropion. The proposed mechanism is ticlopidine inhibition of bupropion hydroxylation via CYP450 2B6. In 12 healthy male volunteers, administration of a single 150 mg dose of bupropion in combination with ticlopidine (250 mg orally twice daily for 4 days) resulted in a 38% increase in bupropion peak plasma concentration (Cmax) and 85% increase in systemic exposure (AUC) compared to administration of bupropion alone. Additionally, the AUC of the hydroxybupropion metabolite decreased by 84% and the AUC ratio of hydroxybupropion to bupropion decreased by 90% with ticlopidine, while oral clearance decreased by 36%.

MANAGEMENT: Caution is advised if bupropion is prescribed with ticlopidine. Pharmacologic response to bupropion should be monitored more closely whenever ticlopidine is added to or withdrawn from therapy, and the bupropion dosage adjusted as necessary. Patients should be advised to contact their physician if they experience potential symptoms of bupropion toxicity such as agitation, anxiety, tremor, insomnia and seizures, or neuropsychiatric symptoms such as delusions, hallucinations, psychosis, impaired concentration, paranoia and confusion.

References

Richter T, Muerdter TE, Heinkele G, et al. "Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine." J Pharmacol Exp Ther 308 (2004): 189-97
Turpeinen M, Tolonen A, Uusitalo J, Jalonen J, Pelkonen O, Laine K "Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation." Clin Pharmacol Ther 77 (2005): 553-9
Turpeinen M, Nieminen R, Juntunen T, Taavitsainen P, Raunio H, Pelkonen O "Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro." Drug Metab Dispos 32 (2004): 626-31
"Product Information. Wellbutrin XL (buPROPion)." GlaxoSmithKline, Philadelphia, PA.

Budeprion SR

Generic Name: bupropion

Brand name: Aplenzin, Budeprion XL, Forfivo XL, Wellbutrin XL, Buproban, Wellbutrin SR, Zyban, Zyban Advantage Pack

Synonyms: Budeprion SR (Oral), Budeprion SR Tablets

What is Budeprion SR?

Ticlopidine

Generic Name: ticlopidine

Brand name: Ticlid

Synonyms: n.a.

What is Ticlopidine?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions