Budeprion XL and Digoxin Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using buPROPion together with digoxin may decrease the blood levels and effects of digoxin. You may need dose adjustments or special tests in order to safely take both medications together. The risk of digoxin toxicity may be increased when buPROPion is stopped. Contact your doctor if your condition changes or if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Limited clinical data suggest that bupropion may reduce digoxin serum levels. The proposed mechanism may involve an increase in digoxin renal clearance via bupropion-mediated activation of digoxin tubular secretion. According to one report, bupropion may increase digoxin renal clearance by as much as 80%.

MANAGEMENT: Caution is advised if digoxin is used with bupropion. Clinical and laboratory monitoring including digoxin serum levels may be appropriate whenever bupropion is added to or withdrawn from therapy. A digoxin dosage adjustment may be considered if an interaction is suspected. The clinician should be aware that the risk of digoxin toxicity may be increased when bupropion is discontinued; patients should be monitored for the development of digoxin toxicity and advised to notify their doctor if they experience nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

Budeprion XL

Generic Name: bupropion

Brand name: Aplenzin, Budeprion XL, Forfivo XL, Wellbutrin XL, Buproban, Wellbutrin SR, Zyban, Zyban Advantage Pack

Synonyms: n.a.

What is Budeprion XL?

Digoxin Intravenous

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin Intravenous?