Bumetanide and Burosumab

• Generic Name: bumetanide
• Dosage Forms: n.a.
• Other Brand Names: Bumex

Bumetanide belongs to a group of medicines called loop diuretics or "water pills." Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

Bumetanide is available only with your doctor's prescription .

• Generic Name: burosumab
• Dosage Forms: n.a.
• Other Brand Names: Crysvita

Burosumab is a monoclonal antibody that targets and blocks the activity of a blood protein called FGF23. In a genetic condition called X-linked hypophosphatemia (HYE-poe-fos-fa-TEEM-ee-a), low phosphate levels in blood are caused by abnormally high levels of FGF23 protein, which causes the kidneys to stop reabsorbing phosphate into the bloodstream.

Blocking the FGF23 protein allows the kidneys to restore and maintain normal phosphate levels. Phosphate is important for the strength of your bones and teeth. Low phosphate levels can lead to bone deformities and growth problems.

Burosumab is used to normalize phosphate levels in adults and children who are at least 1 year old and have X-linked hypophosphatemia.

Burosumab may also be used for purposes not listed in this medication guide.