Bumetanide Tablets and Foscarnet

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Both foscarnet and bumetanide can decrease the calcium levels in your blood. Combining these medications may increase the risk of hypocalcemia, or low blood calcium. Symptoms of hypocalcemia include numbness or tingling around your mouth, muscle spasms, convulsions, mental changes (irritability, depression, psychosis), increased pressure on the brain, and irregular heartbeat. Let your doctor know if you experience these or other unusual symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with other drugs that can reduce serum calcium may potentiate the risk of hypocalcemia associated with foscarnet. Foscarnet chelates with divalent metal ions and causes a dose-related reduction in ionized serum calcium. Hypocalcemia may occur in 15% to 30% of treated patients. Severe hypocalcemia (Trousseau's and Chvostek's signs) and fatalities have been reported rarely in postmarketing surveillance during use of foscarnet in combination with intravenous pentamidine. The interaction has not been reported with other drugs.

MANAGEMENT: Close monitoring is recommended during concomitant use of foscarnet with other drugs that are known to affect calcium concentrations. Serum creatinine and electrolyte levels should be assessed prior to initiating therapy and frequently during therapy. Patients should be advised to promptly notify their physician if they experience potential symptoms of hypocalcemia such as perioral tingling, numbness in extremities, and paresthesias.

Bumetanide Tablets

Generic Name: bumetanide

Brand name: Bumex

Synonyms: Bumetanide (oral/injection), Bumetanide

What is Bumetanide Tablets?

Foscarnet

Generic Name: foscarnet

Brand name: Foscavir

Synonyms: n.a.

What is Foscarnet?