Buphenyl (Sodium Phenylbutyrate Tablets) and Trokendi XR
Determining the interaction of Buphenyl (Sodium Phenylbutyrate Tablets) and Trokendi XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using topiramate together with sodium phenylbutyrate. Topiramate may increase ammonia levels in the blood and reduce the effectiveness of sodium phenylbutyrate in the treatment of urea cycle disorders. You may need a dosage adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Drugs that can increase plasma ammonia levels such as corticosteroids, haloperidol, or the anticonvulsants carbamazepine, topiramate, and phenobarbital may interfere with the therapeutic effects of phenylbutyrate therapy in the management of urea cycle disorders. Corticosteroids can cause the breakdown of body protein, which may lead to increased ammonia levels. The use of haloperidol has been associated with hyperammonemia in a young child with citrullinemia, an inherited disorder of ammonia excretion. The mechanism for haloperidol, carbamazepine, topiramate, and phenobarbital has not been established.
MANAGEMENT: Plasma ammonia levels should be closely monitored when corticosteroids, haloperidol, carbamazepine, topiramate, or phenobarbital are used in patients with urea cycle disorders receiving phenylbutyrate therapy.
- "Product Information. Ravicti (glycerol phenylbutyrate)." Hyperion Therapeutics Inc, South San Francisco, CA.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Buphenyl (sodium phenylbutyrate)." Horizon Pharma USA Inc, Northbrook, IL.
Generic Name: sodium phenylbutyrate
Brand name: Buphenyl
Synonyms: Buphenyl
Generic Name: topiramate
Brand name: Qudexy XR Sprinkle, Topamax, Topamax Sprinkle, Trokendi XR, Qudexy XR, Topiragen
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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