Bupivacaine and Epinephrine and Diastat
Determining the interaction of Bupivacaine and Epinephrine and Diastat and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using diazePAM together with bupivacaine can increase nervous system side effects such as dizziness, drowsiness, and confusion. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until the effects of these medications have worn off. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
Professional:MONITOR: The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.
MANAGEMENT: Caution is advised during concurrent use. Patients should be monitored for potentially excessive or prolonged CNS depression and other CNS adverse effects. Dosage adjustments may be required.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: bupivacaine / epinephrine
Brand name: Marcaine/Epinephrine, Marcaine/Epinephrine PF, Sensorcaine-MPF/EPINEPHrine, Sensorcaine/EPINEPHrine
Synonyms: Bupivacaine and Epinephrine Injection
Generic Name: diazepam
Brand name: Diastat, Diastat AcuDial, Diastat Pediatric, Valium, Diazepam Intensol, Zetran
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bupivacaine and Epinephrine-Diastat AcuDial
- Bupivacaine and Epinephrine-Diastat Pediatric
- Bupivacaine and Epinephrine-Diatrizoate Injection
- Bupivacaine and Epinephrine-Diatrizoate Meglumine
- Bupivacaine and Epinephrine-Diatrizoate Meglumine and Diatrizoate Sodium
- Bupivacaine and Epinephrine-Diatrizoate Meglumine and Iodipamide Meglumine
- Diastat-Bupivacaine and Epinephrine Injection
- Diastat-Bupivacaine Fisiopharma
- Diastat-Bupivacaine Hydrochloride
- Diastat-Bupivacaine Injection
- Diastat-Bupivacaine liposome
- Diastat-Bupivacaine liposome Injection