Bupivacaine Fisiopharma and Phenytoin Sodium, Prompt injection
Determining the interaction of Bupivacaine Fisiopharma and Phenytoin Sodium, Prompt injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One in vitro study has suggested that phenytoin may displace bupivacaine from plasma protein-binding sites. Theoretically, the risk of toxicity from the local anesthetic could increase.
- Ghoneim MM, Pandya H "Plasma protein binding of bupivacaine and its interaction with other drugs in man." Br J Anaesth 46 (1974): 435-8
Generic Name: bupivacaine
Brand name: Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF Spinal, Bupivacaine Fisiopharma, Bupivacaine Spinal, Marcaine, Marcaine Preservative Free, P-Care M, ReadySharp Bupivacaine
Synonyms: Bupivacaine
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bupivacaine Fisiopharma-Phenytoin Suspension
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- Bupivacaine Fisiopharma-Phillips Milk of Magnesia
- Bupivacaine Fisiopharma-Phisohex
- Bupivacaine Fisiopharma-Phl-Fluoxetine
- Bupivacaine Fisiopharma-Phlemex
- Phenytoin Sodium, Prompt injection-Bupivacaine Hydrochloride
- Phenytoin Sodium, Prompt injection-Bupivacaine Injection
- Phenytoin Sodium, Prompt injection-Bupivacaine liposome
- Phenytoin Sodium, Prompt injection-Bupivacaine liposome Injection
- Phenytoin Sodium, Prompt injection-Bupivacaine Spinal
- Phenytoin Sodium, Prompt injection-Buprenex