Bupivacaine Injection and Phenytoin Sodium
Determining the interaction of Bupivacaine Injection and Phenytoin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One in vitro study has suggested that phenytoin may displace bupivacaine from plasma protein-binding sites. Theoretically, the risk of toxicity from the local anesthetic could increase.
- Ghoneim MM, Pandya H "Plasma protein binding of bupivacaine and its interaction with other drugs in man." Br J Anaesth 46 (1974): 435-8
Generic Name: bupivacaine
Brand name: Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF Spinal, Bupivacaine Fisiopharma, Bupivacaine Spinal, Marcaine, Marcaine Preservative Free, P-Care M, ReadySharp Bupivacaine
Synonyms: Bupivacaine (Injection), Bupivacaine
Generic Name: phenytoin
Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Phenytoin Sodium-Bupivacaine liposome
- Phenytoin Sodium-Bupivacaine liposome Injection
- Phenytoin Sodium-Bupivacaine Spinal
- Phenytoin Sodium-Buprenex
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- Phenytoin Sodium-Buprenorphine