Bupivacaine liposome and Clidinium and Chlordiazepoxide
Determining the interaction of Bupivacaine liposome and Clidinium and Chlordiazepoxide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using chlordiazePOXIDE together with bupivacaine liposome can increase nervous system side effects such as dizziness, drowsiness, and confusion. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until the effects of these medications have worn off. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
Professional:MONITOR: The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.
MANAGEMENT: Caution is advised during concurrent use. Patients should be monitored for potentially excessive or prolonged CNS depression and other CNS adverse effects. Dosage adjustments may be required.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: bupivacaine liposome
Brand name: Exparel
Synonyms: Bupivacaine (Liposomal)
Generic Name: chlordiazepoxide / clidinium
Brand name: Librax, Clindex, Chlordinium
Synonyms: Chlordiazepoxide and clidinium, Chlordiazepoxide and Clidinium Capsules
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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