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Buprenex and Victrelis

Determining the interaction of Buprenex and Victrelis and the possibility of their joint administration.

Check result:

Buprenex <> Victrelis

Relevance: 09.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Boceprevir may alter the blood levels and effects of buprenorphine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with the hepatitis C virus NS3/4A protease inhibitor, boceprevir, may alter the plasma concentrations of methadone and buprenorphine. The interaction has not been specifically studied with boceprevir, but has been reported in patients receiving methadone and buprenorphine with HIV protease inhibitors. In some cases, plasma concentrations of the opioid are increased, while in others, plasma concentrations are decreased.

MANAGEMENT: Clinical monitoring is recommended if buprenorphine or methadone is used in combination with boceprevir.

References

"Product Information. Victrelis (boceprevir)." Schering-Plough Corporation, Kenilworth, NJ.
"Product Information. Incivek (telaprevir)." Vertex Pharmaceuticals, Cambridge, MA.

Buprenex

Generic Name: buprenorphine

Brand name: Buprenex, Belbuca, Probuphine, Butrans, Sublocade, Subutex

Synonyms: Buprenex (injection - Buprenex)

What is Buprenex?

Victrelis

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: n.a.

What is Victrelis?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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