Buprenorphine and Naloxone Sublingual Film (Suboxone) and Methylnaltrexone
Determining the interaction of Buprenorphine and Naloxone Sublingual Film (Suboxone) and Methylnaltrexone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Concomitant use of methylnaltrexone with other opioid antagonists may result in additive pharmacologic effects and increased risk of opioid withdrawal. Symptoms consistent with opioid withdrawal including hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, and yawning have occurred in patients treated with methylnaltrexone. MANAGEMENT: Concomitant use of methylnaltrexone with other opioid antagonists should generally be avoided. References "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories, Philadelphia, PA.
Professional:GENERALLY AVOID: Concomitant use of methylnaltrexone with other opioid antagonists may result in additive pharmacologic effects and increased risk of opioid withdrawal. Symptoms consistent with opioid withdrawal including hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, and yawning have occurred in patients treated with methylnaltrexone.
MANAGEMENT: Concomitant use of methylnaltrexone with other opioid antagonists should generally be avoided.
- "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories, Philadelphia, PA.
Generic Name: buprenorphine / naloxone
Brand name: Bunavail, Suboxone, Zubsolv
Synonyms: Buprenorphine and naloxone (oral/sublingual), Buprenorphine and Naloxone
Generic Name: methylnaltrexone
Brand name: Relistor
Synonyms: Methylnaltrexone (oral/injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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