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Buprenorphine and Naloxone Sublingual Tablets and Relistor (Methylnaltrexone Tablets)

Determining the interaction of Buprenorphine and Naloxone Sublingual Tablets and Relistor (Methylnaltrexone Tablets) and the possibility of their joint administration.

Check result:
Buprenorphine and Naloxone Sublingual Tablets <> Relistor (Methylnaltrexone Tablets)
Relevance: 22.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Concomitant use of methylnaltrexone with other opioid antagonists may result in additive pharmacologic effects and increased risk of opioid withdrawal. Symptoms consistent with opioid withdrawal including hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, and yawning have occurred in patients treated with methylnaltrexone. MANAGEMENT: Concomitant use of methylnaltrexone with other opioid antagonists should generally be avoided. References "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories, Philadelphia, PA.

Professional:

GENERALLY AVOID: Concomitant use of methylnaltrexone with other opioid antagonists may result in additive pharmacologic effects and increased risk of opioid withdrawal. Symptoms consistent with opioid withdrawal including hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, and yawning have occurred in patients treated with methylnaltrexone.

MANAGEMENT: Concomitant use of methylnaltrexone with other opioid antagonists should generally be avoided.

References
  • "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories, Philadelphia, PA.
Buprenorphine and Naloxone Sublingual Tablets

Generic Name: buprenorphine / naloxone

Brand name: Bunavail, Suboxone, Zubsolv

Synonyms: Buprenorphine and naloxone (oral/sublingual), Buprenorphine and Naloxone

Relistor (Methylnaltrexone Tablets)

Generic Name: methylnaltrexone

Brand name: Relistor

Synonyms: Relistor

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.