Bupropion and Coumadin Injection
Determining the interaction of Bupropion and Coumadin Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using warfarin together with buPROPion may cause you to bleed more easily. You may need a dose adjustment based on your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Altered PT or INR, infrequently associated with hemorrhagic or thrombotic complications, has been observed during coadministration of bupropion and warfarin. The mechanism of interaction is unknown. In patients taking bupropion for smoking cessation, physiological changes resulting from smoking cessation itself may alter the pharmacokinetics of warfarin. Tobacco smoke is an inducer of hepatic microsomal enzymes, thus smoking cessation may increase blood concentrations of warfarin and other drugs that are extensively metabolized due to de-induction of the enzymes.
MANAGEMENT: Caution is advised if warfarin is given with bupropion. The INR should be checked regularly and warfarin dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of bupropion in patients who are stabilized on their warfarin regimen. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- "Product Information. Zyban (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Wellbutrin (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: bupropion
Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL
Synonyms: BuPROPion
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bupropion-Covaryx
- Bupropion-Covaryx HS
- Bupropion-Covera-HS
- Bupropion-Cozaar
- Bupropion-CPB WC
- Bupropion-CPM-PSE DM Drops
- Coumadin Injection-Bupropion and naltrexone
- Coumadin Injection-Bupropion Extended-Release Tablets
- Coumadin Injection-Bupropion Hydrochloride
- Coumadin Injection-Bupropion SR Tablets
- Coumadin Injection-Bupropion Sustained-Release Tablets (Smoking Deterrent)
- Coumadin Injection-Bupropion Tablets