Bupropion Hydrochloride and Carbidopa and Levodopa ODT
Determining the interaction of Bupropion Hydrochloride and Carbidopa and Levodopa ODT and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using buPROPion together with levodopa may add to the side effects of either medication. This may be more likely to occur in older adults or those with a debilitating condition. Contact your doctor if you experience loss of muscle coordination, dizziness, vertigo, agitation, tremors, and shuffling of your feet. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: According to the product labeling for bupropion, limited clinical data suggest a higher incidence of adverse experiences in patients receiving bupropion concurrently with either levodopa or amantadine. Neither the mechanism of interaction nor specific adverse effects are cited. According to a published case report, neurotoxic effects including ataxia, dizziness, vertigo, agitation, tremors, and gait abnormalities occurred in 3 elderly patients following addition of amantadine to bupropion therapy. The symptoms resolved within 72 hours after discontinuation of both drugs. The authors theorize that additive central dopaminergic effects of the drugs may have caused the apparent interaction.
MANAGEMENT: Caution is advised if bupropion is used with levodopa or amantadine. The manufacturer recommends a lower initial dosage of bupropion and gradual dosage increments in patients receiving the drugs concurrently.
- Trappler B, Miyashiro AM "Bupropion-amantadine-associated neurotoxicity." J Clin Psychiatry 61 (2000): 61-2
- "Product Information. Wellbutrin (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: bupropion
Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL
Synonyms: Bupropion, BuPROPion
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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