Bupropion Hydrochloride and Oxaprozin Potassium

• Generic Name: bupropion
• Dosage Forms: n.a.
• Other Brand Names: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL

Treatment of major depressive disorder.

May be useful (alone or in combination with other antidepressants) in patients with refractory depression.

Seasonal Affective Disorder

Prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD; also referred to as winter depression).

Smoking Cessation

Adjunct in the cessation of smoking (alone or in combination with nicotine replacement therapy).

US Public Health Service (USPHS) guideline for the treatment of tobacco use and dependence recommends bupropion (as extended-release tablets) as one of several first-line drugs that may reliably increase long-term smoking abstinence rates.

Depression Associated with Bipolar Disorder

Treatment of patients with bipolar depression (bipolar disorder, depressive episode).

American Psychiatric Association (APA) considers bupropion one of several second-line agents for use when first-line agents are ineffective or not tolerated.

Attention Deficit Hyperactivity Disorder (ADHD)

Used in a limited number of children and adults in the management of ADHD.

Panic Disorder

Ineffective in the treatment of panic disorder and concomitant phobic disorder, but may improve symptoms of panic and depression in patients with major depression who have superimposed panic symptoms.

Bulimia Nervosa

Not recommended by APA for bulimia nervosa because associated with seizures in purging bulimic patients.

• Generic Name: oxaprozin
• Dosage Forms: n.a.
• Other Brand Names: Daypro

Consider potential benefits and risks of oxaprozin therapy as well as alternative therapies before initiating therapy with the drug. Use lowest effective dosage and shortest duration of therapy consistent with the patient’s treatment goals.

Symptomatic treatment of osteoarthritis and rheumatoid arthritis.

Management of juvenile rheumatoid arthritis in children 6-16 years of age.