Bupropion SR Tablets and Me-PB-Hyos Tablets
Determining the interaction of Bupropion SR Tablets and Me-PB-Hyos Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using buPROPion, tell your doctor if you also use PHENobarbital. PHENobarbital may be prescribed to treat agitation, anxiety, and insomnia associated with buPROPion use, you should be alerted to the possibility of an increased risk of seizures during excessive exposure to these drugs. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Excessive use or abrupt discontinuation of barbiturates and other sedatives after chronic ingestion may precipitate seizures in patients receiving bupropion. Theoretically, barbiturates may also decrease the plasma concentrations and pharmacologic effects of bupropion due to induction of hepatic CYP450 isoenzymes.
MANAGEMENT: Pharmacologic response to bupropion should be monitored more closely whenever a barbiturate is added to or withdrawn from therapy, and the bupropion dosage adjusted as necessary. Although barbiturates and other sedatives may be prescribed to treat agitation, anxiety, and insomnia associated with bupropion use, patients should be alerted to the possibility of an increased risk of seizures during excessive exposure to these drugs. Patients should not attempt to alter the dosages or discontinue the medications on their own without consulting with their physician. The use of bupropion is contraindicated in patients undergoing abrupt discontinuation of sedatives.
- "Product Information. Wellbutrin (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
- James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4
Generic Name: bupropion
Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL
Synonyms: Bupropion, BuPROPion
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Me-PB-Hyos Elixir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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