Bupropion Sustained-Release Tablets (Smoking Deterrent) and Depakote Sprinkles

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Divalproex sodium may increase the blood levels of buPROPion. Contact your doctor if you experience increased side effects or your condition changes. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggest that coadministration of bupropion with valproic acid may increase the plasma concentrations of the active metabolite, hydroxybupropion. The mechanism of interaction has not been established, but may involve inhibition of the metabolism of hydroxybupropion. In five study patients with mood disorders, administration of a single 150 mg dose of bupropion during valproate therapy (mean dose 1750 mg/day for at least 3 weeks) increased mean hydroxybupropion peak plasma concentration (Cmax) and systemic exposure (AUC) by 56% and 94%, respectively, compared to administration with placebo. The clinical significance of these changes is unknown. A case report describes a patient treated with bupropion who developed visual and auditory hallucinations when valproic acid was substituted for lithium. It is unclear whether a pharmacokinetic or pharmacodynamic interaction may have been involved. An increase of nearly 30% in valproate levels following the addition of bupropion has also been reported in one patient.

MANAGEMENT: Until more information is available, serum drug levels and pharmacologic effects should be monitored more closely during coadministration of bupropion and valproic acid. Dosage adjustments may be required if an interaction is suspected.

Bupropion Sustained-Release Tablets (Smoking Deterrent)

Generic Name: bupropion

Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL

Synonyms: Bupropion, BuPROPion

What is Bupropion Sustained-Release Tablets (Smoking Deterrent)?

Depakote Sprinkles

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote

Synonyms: Depakote Capsules

What is Depakote Sprinkles?