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Buspar and Ketoconazole (Systemic)

Determining the interaction of Buspar and Ketoconazole (Systemic) and the possibility of their joint administration.

Check result:

Buspar <> Ketoconazole (Systemic)

Relevance: 11.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before using ketoconazole, tell your doctor if you also use busPIRone. This can cause drowsiness, feeling light-headed, uneven heart rate, depressed mood, unusual thoughts or behavior, or lack coordination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The combination of buspirone with azole antifungals may lead to significantly elevated buspirone plasma concentrations. In one study conducted in healthy volunteers, the average buspirone area under the plasma concentration-time curve (AUC) increased 19-fold and peak plasma concentrations increased 13-fold, after pretreatment with itraconazole. The probable mechanism is competitive inhibition of CYP450 3A4 first-pass metabolism by the antifungal.

MANAGEMENT: Close clinical observation is recommended if patients receiving buspirone are started on, stopped or receive a dose change of an azole antifungal. If buspirone is started in a patient currently receiving an azole antifungal, the clinician may wish to initiate buspirone doses conservatively. Patients should be cautioned about increased CNS side effects including dizziness, drowsiness, and impaired psychomotor performance.

References

Kivisto KT, Lamberg TS, Kantola T, Neuvonen PJ "Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole." Clin Pharmacol Ther 62 (1997): 348-54
Kivisto KT, Lamberg TS, Neuvonen PJ "Interactions of buspirone with itraconazole and rifampicin: Effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone." Pharmacol Toxicol 84 (1999): 94-7

Buspar

Generic Name: buspirone

Brand name: Buspar, Buspar Dividose, Vanspar, Buspirex, Bustab, LinBuspirone

Synonyms: BuSpar

What is Buspar?

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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