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Buspar and PCE Dispertab

Determining the interaction of Buspar and PCE Dispertab and the possibility of their joint administration.

Check result:

Buspar <> PCE Dispertab

Relevance: 11.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before using erythromycin, tell your doctor if you also use busPIRone. This can cause drowsiness, feeling light-headed, uneven heart rate, depressed mood, unusual thoughts or behavior, or lack coordination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The combination of buspirone and some macrolide antibiotics may lead to elevated buspirone concentrations and adverse effects. The mechanism may be due to macrolide inhibition of CYP450 3A4 metabolism of buspirone. In one study, concomitant administration of buspirone with erythromycin resulted in a 5-fold and 6-fold increase in Cmax and AUC, respectively, of buspirone concentrations.

MANAGEMENT: Patients should be monitored for adverse buspirone effects, such as increased sedation. A reduction in dosage of buspirone may be necessary. Some authorities suggest a buspirone dose of 2.5 mg twice daily with subsequent dose adjustments based on clinical response.

References

Kivisto KT, Lamberg TS, Kantola T, Neuvonen PJ "Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole." Clin Pharmacol Ther 62 (1997): 348-54
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Buspar (buspirone)." Bristol-Myers Squibb, Princeton, NJ.

Buspar

Generic Name: buspirone

Brand name: Buspar, Buspar Dividose, Vanspar, Buspirex, Bustab, LinBuspirone

Synonyms: BuSpar

What is Buspar?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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