Buspirone and Verelan PM

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before using verapamil, tell your doctor if you also use busPIRone. This can cause drowsiness, feeling light-headed, uneven heart rate, depressed mood, unusual thoughts or behavior, or lack coordination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant administration of verapamil may increase plasma buspirone concentrations. In one study with healthy subjects, buspirone area under the plasma concentration-time curve (AUC) and peak plasma concentrations increased by more than 3-fold. The proposed mechanism is inhibition of CYP3A4 mediated first pass metabolism by verapamil.

MANAGEMENT: If this combination is to be used, the patient should be monitored carefully for signs of buspirone toxicity. Alternatively, use of a dihydropyridine calcium channel blocker or an anxiolytic which is not a substrate of CYP3A4 metabolism may be appropriate. Patients should be monitored for increased sedation and dizziness, and cautioned about possible impaired psychomotor performance.

Buspirone

Generic Name: buspirone

Brand name: Buspar, Buspar Dividose, Vanspar, Buspirex, Bustab, LinBuspirone

Synonyms: BusPIRone

What is Buspirone?

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

What is Verelan PM?