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Busulfan Concentrate Injection and Tylenol Cold

Determining the interaction of Busulfan Concentrate Injection and Tylenol Cold and the possibility of their joint administration.

Check result:

Busulfan Concentrate Injection <> Tylenol Cold

Relevance: 12.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using acetaminophen together with busulfan may increase the effects of busulfan. If your doctor prescribes these two drugs, you may need a dose adjustment or special tests to safely use both. Contact your doctor if you notice any of the side effects of busulfan, which may include bleeding or bruising, seizures, fever or chills, persistent cough, congestion, or breathing problems. You may also notice pain in the stomach or back, nausea, vomiting, or diarrhea. Also, these can be accompanied by decreased appetite or weight loss. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theoretically, coadministration with acetaminophen may increase the plasma concentrations of busulfan. The proposed mechanism is decreased busulfan clearance via conjugation due to reduced levels of glutathione in blood and tissues caused by acetaminophen.

MANAGEMENT: Patients receiving busulfan therapy should be monitored more closely for toxicity (e.g., myelosuppression, seizures) if acetaminophen is administered concurrently. When busulfan is administered intravenously, acetaminophen should preferably be avoided within 72 hours prior to and during infusion of busulfan to minimize risk of an interaction.

References

"Product Information. Busulfex (busulfan)." ESP Pharma Inc, Edison, NJ.

Busulfan Concentrate Injection

Generic Name: busulfan

Brand name: Busulfex, Myleran

Synonyms: Busulfan (oral/injection), Busulfan

What is Busulfan Concentrate Injection?

Tylenol Cold

Generic Name: acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine

Brand name: Alka-Seltzer Plus-D Sinus/Cold, Cold Symptoms Relief Maximum Strength, EQ Cold Relief Complete, EQ Cold/Cough Plus, EQL Pain Relief/Cold, Tylenol Cold and Flu Powder, Theraflu Flu, Cold and Cough Powder, Theraflu Nightime Maximum Strength, Comtrex Day and Night, Theraflu Night Cough and Cold and Flu, Co-Apap, Vicks Formula 44M, Cough Formula M Multi-Symptom, Mapap Cold, Child Tylenol Cold Multi-Symptom Plus Cough, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Robitussin Honey Flu Nighttime, Children's Tylenol Flu, Alka-Seltzer Plus Cough and Cold Liquigel, Tylenol Cold Complete Formula, Children's Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Triaminic Flu, Cough & Fever, Theraflu Cold & Cough, Theraflu Severe Cold & Congestion, Theraflu Flu & Cough, Tylenol Cold Day/Night Convenience Pack, Childrenâ€™s Non-Aspirin Cold/Cough, EQL Pain Relief Plus Cold/Cough, Tylenol Childrenâ€™s Cold/Cough

Synonyms: n.a.

What is Tylenol Cold?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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