Busulfan Intravenous and Ciprofloxacin in 5% Dextrose
Determining the interaction of Busulfan Intravenous and Ciprofloxacin in 5% Dextrose and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that chemotherapy with antineoplastic agents may reduce the plasma concentrations of oral quinolone antibiotics. The proposed mechanism is decreased quinolone absorption secondary to alteration of intestinal mucosa by cancer chemotherapy. In six patients with newly diagnosed hematologic malignancy, treatment with various antineoplastic agents (cyclophosphamide, cytarabine, daunorubicin, doxorubicin, mitoxantrone, prednisolone, vincristine) decreased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC 0 to 4 hours) of ciprofloxacin by approximately 46% each. Data are not available for other quinolone antibiotics.
- Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42
Generic Name: busulfan
Brand name: Busulfex, Myleran
Synonyms: Busulfan (oral/injection), Busulfan
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: Ciprofloxacin, Ciprofloxacin (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Busulfan Intravenous-Ciprofloxacin injection
- Busulfan Intravenous-Ciprofloxacin Injection Concentrate
- Busulfan Intravenous-Ciprofloxacin Intravenous
- Busulfan Intravenous-Ciprofloxacin Oral Suspension
- Busulfan Intravenous-Ciprofloxacin Tablets
- Busulfan Intravenous-Cisapride Suspension
- Ciprofloxacin in 5% Dextrose-Busulfan oral/injection
- Ciprofloxacin in 5% Dextrose-Busulfan Tablet
- Ciprofloxacin in 5% Dextrose-Busulfex
- Ciprofloxacin in 5% Dextrose-Butabarbital
- Ciprofloxacin in 5% Dextrose-Butalbital and Acetaminophen
- Ciprofloxacin in 5% Dextrose-Butalbital and Acetaminophen Capsule