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Busulfex and Theraflu Warming Severe Cold Daytime

Determining the interaction of Busulfex and Theraflu Warming Severe Cold Daytime and the possibility of their joint administration.

Check result:

Busulfex <> Theraflu Warming Severe Cold Daytime

Relevance: 14.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using acetaminophen together with busulfan may increase the effects of busulfan. If your doctor prescribes these two drugs, you may need a dose adjustment or special tests to safely use both. Contact your doctor if you notice any of the side effects of busulfan, which may include bleeding or bruising, seizures, fever or chills, persistent cough, congestion, or breathing problems. You may also notice pain in the stomach or back, nausea, vomiting, or diarrhea. Also, these can be accompanied by decreased appetite or weight loss. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theoretically, coadministration with acetaminophen may increase the plasma concentrations of busulfan. The proposed mechanism is decreased busulfan clearance via conjugation due to reduced levels of glutathione in blood and tissues caused by acetaminophen.

MANAGEMENT: Patients receiving busulfan therapy should be monitored more closely for toxicity (e.g., myelosuppression, seizures) if acetaminophen is administered concurrently. When busulfan is administered intravenously, acetaminophen should preferably be avoided within 72 hours prior to and during infusion of busulfan to minimize risk of an interaction.

References

"Product Information. Busulfex (busulfan)." ESP Pharma Inc, Edison, NJ.

Busulfex

Generic Name: busulfan

Brand name: Busulfex, Myleran

Synonyms: n.a.

What is Busulfex?

Theraflu Warming Severe Cold Daytime

Generic Name: acetaminophen / dextromethorphan / phenylephrine

Brand name: Comtrex Cold & Cough, DayQuil Cold & Flu, Daytime, Flu & Severe Cold & Cough Daytime Powder, Mapap Cold Formula, Robitussin Peak Cold Daytime Cold + Flu, Sudafed PE Pressure+Pain+Cough, Theraflu Daytime Severe Cold & Cough, Theraflu Warming Severe Cold Daytime, Tylenol Cold Multi-Symptom Daytime, Vicks Dayquil Liquicaps Cold/Flu, Contac Complete Cough, Cold & Flu Extra Strength, Tylenol Cold Daytime, Neocitran Non Drowsy Extra Strength Cold and Flu, Tylenol Cold Daytime Extra Strength, Tylenol Flu Daytime Extra Strength, Theraflu Nighttime Severe Cold & Cough, Theraflu Warming Relief Daytime Multi-Symptom Cold, Tylenol Children's Plus Cold & Cough, Theraflu Multi-Symptom Severe Cold, Day Time Cold & Flu, DayQuil Nature Fusion Cold & Flu, Theraflu ExpressMax Day Cold & Cough, Tylenol Cold Max Day, Mucinex Fast-Max Severe Cold and Sinus, Mucinex Fast-Max Congestion and Headache, Theraflu PowerPods Daytime Severe Cold, Comtrex Cold and Cough Maximum Strength, Vicks DayQuil Multi-Symptom Cold/Flu Relief

Synonyms: n.a.

What is Theraflu Warming Severe Cold Daytime?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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