Butalbital and Acetaminophen Capsule and Panhematin
Determining the interaction of Butalbital and Acetaminophen Capsule and Panhematin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using butalbital together with hemin. Using these medications together may cause hemin to be less effective. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with drugs that are capable of increasing the activity of delta-aminolevulinic acid synthetase (e.g., estrogens, barbiturates, steroid metabolites, rifampin) may negate the pharmacologic effect of hemin. In the treatment of porphyria, hemin is thought to limit the rate of porphyrin/heme biosynthesis by inhibiting delta-aminolevulinic acid synthetase, thus any induction of this enzyme would be expected to counteract the therapeutic effect of hemin.
MANAGEMENT: Drugs capable of increasing the activity of delta-aminolevulinic acid synthetase should be avoided during hemin therapy.
- "Product Information. Panhematin (hemin)." Recordati Rare Diseases Inc, Lebanon, NJ.
Generic Name: acetaminophen / butalbital
Brand name: Allzital, Bupap, Phrenilin, Triaprin, Phrenilin Forte, Bucet, Axocet, Sedapap, Dolgic, Marten-Tab, Tencon, Prominol, Cephadyn, Butex Forte, Promacet, Orbivan CF
Synonyms: Acetaminophen and butalbital, Butalbital and Acetaminophen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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