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Butisol Sodium and Grifulvin V

Determining the interaction of Butisol Sodium and Grifulvin V and the possibility of their joint administration.

Check result:

Butisol Sodium <> Grifulvin V

Relevance: 17.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using butabarbital together with griseofulvin may decrease the effects of griseofulvin. Contact your doctor if your infection worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Barbiturates may decrease serum griseofulvin levels. The mechanism may be related to decreased absorption of griseofulvin. Therapeutic failure has been reported. Phenobarbital and primidone are the only barbiturates specifically implicated in this interaction. However, other barbiturates may behave in a similar fashion.

MANAGEMENT: Patients should be monitored for reduced antifungal efficacy. It may be necessary to increase griseofulvin doses or use alternative therapeutic agents.

References

Kraml M, Marton AV, Dvornik D, Chappel C, Garbaczewska L "Effect of primidone (Mysoline) on tissular levels of griseofulvin in the rat." Proc Soc Exp Biol Med 120 (1965): 678-9
Riegelman S, Rowland M, Epstein WL "Griseofulvin-phenobarbital interaction in man." JAMA 213 (1970): 426-31
Busfield D, Child KJ, Atkinson RM, Tomich EG "An effect of phenobarbitone on blood-levels of griseofulvin in man." Lancet 2 (1963): 1042-3

Butisol Sodium

Generic Name: butabarbital

Brand name: Butisol Sodium, Busodium

Synonyms: n.a.

What is Butisol Sodium?

Grifulvin V

Generic Name: griseofulvin

Brand name: Grifulvin V, Fulvicin P/G, Fulvicin U/F, Gris-PEG, Grisactin Ultra, Grisactin 250, Grisactin 500, Griseofulicin, Griseofulvic

Synonyms: Grifulvin V Tablets

What is Grifulvin V?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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