Butisol Sodium and Kisqali Femara Co-Pack
Determining the interaction of Butisol Sodium and Kisqali Femara Co-Pack and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Butabarbital may reduce the blood levels of ribociclib. In some cases, this may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ribociclib, which is a substrate of the isoenzyme. Physiologically-based pharmacokinetic simulations (PBPK) suggest that a moderate CYP450 3A4 inducer, efavirenz, may decrease ribociclib Cmax and AUC by 37% and 60%, respectively. However, data with less potent CYP450 3A4 inducers are limited.
MANAGEMENT: The potential for diminished therapeutic effects of ribociclib should be considered when prescribed with inducers of CYP450 3A4, particularly moderate inducers including efavirenz and nevirapine. Pharmacologic effects of ribociclib should be monitored more closely whenever an inducer is added to or withdrawn from therapy. Alternative treatment may be required if an interaction is suspected.
- "Product Information. Kisqali (ribociclib)." Novartis Pharmaceuticals, East Hanover, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: butabarbital
Brand name: Butisol Sodium, Busodium
Synonyms: n.a.
Generic Name: letrozole / ribociclib
Brand name: Kisqali Femara Co-Pack 200 mg-25 mg Dose, Kisqali Femara Co-Pack 400 mg-25 mg Dose, Kisqali Femara Co-Pack 600 mg-25 mg Dose
Synonyms: Kisqali Femara Co-Pack 200 mg-2.5 mg Dose
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Butisol Sodium-Kisqali Femara Co-Pack 200 mg-2.5 mg Dose
- Butisol Sodium-Kisqali Femara Co-Pack 400 mg-2.5 mg Dose
- Butisol Sodium-Kisqali Femara Co-Pack 600 mg-2.5 mg Dose
- Butisol Sodium-Kitabis Pak
- Butisol Sodium-Kitabis Pak inhalation
- Butisol Sodium-Klofensaid II
- Kisqali Femara Co-Pack-Butorphanol
- Kisqali Femara Co-Pack-Butorphanol injection
- Kisqali Femara Co-Pack-Butorphanol Injection Solution
- Kisqali Femara Co-Pack-Butorphanol nasal
- Kisqali Femara Co-Pack-Butorphanol Nasal Solution
- Kisqali Femara Co-Pack-Butorphanol Nasal Spray