Bydureon Pen and Ginseng

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration of ginseng with antidiabetic drugs may potentiate the risk of hypoglycemia. Clinical data are conflicting. Some small studies have reported that ginseng reduced the blood levels of glucose and/or glycosylated hemoglobin (HbA1C) in diabetic patients, whereas others have not. Furthermore, the lack of standardized preparations of ginseng may limit the generalization of study results. In a double-blind, randomized cross-over trial, 24 diabetic patients received either 1 g/meal (3 g/day) of American ginseng (AG) extract or placebo for 8 weeks while maintaining their original antidiabetic treatments. Compared to placebo, AG significantly reduced HbA1c by 0.29% and fasting blood glucose by 0.71 mmol/L. In another study, 36 non-insulin dependent diabetic patients received 100 mg or 200 mg ginseng extract containing 4 mg or 8 mg of ginsenoside, respectively or placebo once daily for 8 weeks. Compared to placebo, HbA1C was reduced by 0.5% and fasting blood glucose by 0.9 mmol/L in the 200 mg ginseng extract group. However, in contrast, other randomized, double-blind, placebo controlled studies reported no effect of ginseng on HbA1C. MANAGEMENT: Until more information is available, blood glucose should be monitored if antidiabetic agents are used concomitantly with ginseng. Patients should be advised on the potential signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia), how to treat it, and to contact their doctor if it occurs. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery. References Vuksan V, Sung MK, Sievenpiper JL, et.al "Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety." Nutr Metab Cardiovasc Dis 18 (2008): 46-56 Sotaniemi EA, Haapakoski E, Rautio A "Ginseng therapy in non-insulin-dependent diabetic patients." Diabetes Care 18 (1995): 1373-5 Carabin IG, Burdock GA, Chatzidakis C "Safety assessment of panax ginseng." Int J Toxicol 19 (2000): 293-301 Win HH, Anderson R "Hypoglycemia due to "conception-enhancing" oral supplement." Endocr Pract 24 (2019): 88-9 Vuksan V, Sievenpiper JL, Koo VY, et.al "Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo controlled trial." Arch Intern Med 160 (2000): 1009-13 Vuskan V, Xu ZZ, Jovanovski E, et.al "Efficacy and safety of American ginseng (Panax quinquefolius L) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial." Eur J Nutr 58 (2019): 1237-45 Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13 View all 7 references

MONITOR: Coadministration of ginseng with antidiabetic drugs may potentiate the risk of hypoglycemia. Clinical data are conflicting. Some small studies have reported that ginseng reduced the blood levels of glucose and/or glycosylated hemoglobin (HbA1C) in diabetic patients, whereas others have not. Furthermore, the lack of standardized preparations of ginseng may limit the generalization of study results. In a double-blind, randomized cross-over trial, 24 diabetic patients received either 1 g/meal (3 g/day) of American ginseng (AG) extract or placebo for 8 weeks while maintaining their original antidiabetic treatments. Compared to placebo, AG significantly reduced HbA1c by 0.29% and fasting blood glucose by 0.71 mmol/L. In another study, 36 non-insulin dependent diabetic patients received 100 mg or 200 mg ginseng extract containing 4 mg or 8 mg of ginsenoside, respectively or placebo once daily for 8 weeks. Compared to placebo, HbA1C was reduced by 0.5% and fasting blood glucose by 0.9 mmol/L in the 200 mg ginseng extract group. However, in contrast, other randomized, double-blind, placebo controlled studies reported no effect of ginseng on HbA1C.

MANAGEMENT: Until more information is available, blood glucose should be monitored if antidiabetic agents are used concomitantly with ginseng. Patients should be advised on the potential signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia), how to treat it, and to contact their doctor if it occurs. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery.

Bydureon Pen

Generic Name: exenatide

Brand name: Bydureon, Bydureon BCise, Bydureon Pen, Bydureon Tray, Byetta Prefilled Pen

Synonyms: Bydureon

What is Bydureon Pen?

Ginseng

Generic Name: ginseng

Brand name:

Synonyms: n.a.

What is Ginseng?