Bydureon Pen and Jantoven

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with exenatide may cause you to bleed more easily. You may need a dose adjustment based on your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Spontaneous reports of increased INR, sometimes accompanied by bleeding, have been associated with concomitant use of warfarin and exenatide. The mechanism of interaction is unknown. In a controlled study in healthy volunteers, the time to reach peak plasma concentration (Tmax) of warfarin was delayed by about two hours when warfarin was administered 30 minutes after exenatide. However, no clinically relevant effects on peak plasma concentration (Cmax) or systemic exposure (AUC) were observed.

MANAGEMENT: Until more data are available, caution is advised if exenatide is prescribed to patients treated with warfarin. The INR should be checked frequently and warfarin dosage adjusted accordingly, particularly following initiation or discontinuation of exenatide in patients who are stabilized on their warfarin regimen. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Bydureon Pen

Generic Name: exenatide

Brand name: Bydureon, Bydureon BCise, Bydureon Pen, Bydureon Tray, Byetta Prefilled Pen

Synonyms: Bydureon

What is Bydureon Pen?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?