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Bydureon Pen and Omeprazole, Clarithromycin, and Amoxicillin

Determining the interaction of Bydureon Pen and Omeprazole, Clarithromycin, and Amoxicillin and the possibility of their joint administration.

Check result:

Bydureon Pen <> Omeprazole, Clarithromycin, and Amoxicillin

Relevance: 25.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using clarithromycin together with insulin and some other diabetes medications has occasionally resulted in hypoglycemia, or low blood sugar. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Talk to your doctor or pharmacist if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring of your blood sugar if you are receiving treatment for diabetes and are starting clarithromycin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of insulin and other antidiabetic agents with clarithromycin may cause significant hypoglycemia. There have been rare reports of hypoglycemia in patients treated with clarithromycin, some of whom were taking oral hypoglycemic agents or insulin. The exact mechanism of interaction has not been established. With certain hypoglycemic drugs such as nateglinide, pioglitazone, repaglinide and rosiglitazone, inhibition of the CYP450 3A4 isoenzyme by clarithromycin may be involved.

MANAGEMENT: Caution is advised if clarithromycin is prescribed to patients receiving antidiabetic agents. Patients should be advised to regularly monitor their blood sugar and counseled on how to recognize and treat hypoglycemia, which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia.

References

"Product Information. Biaxin (clarithromycin)." Abbott Pharmaceutical, Abbott Park, IL.
Otsuka SH "Severe hypoglycemia from helicobacter pylori triple-drug therapy and insulin detemir drug interaction." Pharmacotherapy 33 (2013): e45-9
Niemi M, Neuvonen PJ, Kivisto KT "The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 70 (2001): 58-65
Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Leiba A, Leibowitz A, Grossman E "An unusual case of hypoglycemia in a diabetic patient." Ann Emerg Med 44 (2004): 427-8
Bussing R, Gende A "Severe hypoglycemia from clarithromycin-sulfonylurea drug interaction." Diabetes Care 25 (2002): 1659-61
Schelleman H, Bilker WB, Brensinger CM, Wan F, Hennessy S "Anti-infectives and the risk of severe hypoglycemia in users of glipizide or glyburide." Clin Pharmacol Ther 88 (2010): 214-22

Bydureon Pen

Generic Name: exenatide

Brand name: Bydureon, Bydureon BCise, Bydureon Pen, Bydureon Tray, Byetta Prefilled Pen

Synonyms: Bydureon

What is Bydureon Pen?

Omeprazole, Clarithromycin, and Amoxicillin

Generic Name: amoxicillin / clarithromycin / omeprazole

Brand name: Omeclamox-Pak

Synonyms: Amoxicillin, clarithromycin, and omeprazole

What is Omeprazole, Clarithromycin, and Amoxicillin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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