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Bydureon Pen and ReliOn/Novolin 70/30

Determining the interaction of Bydureon Pen and ReliOn/Novolin 70/30 and the possibility of their joint administration.

Check result:
Bydureon Pen <> ReliOn/Novolin 70/30
Relevance: 25.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using exenatide together with insulin regular can increase the risk of hypoglycemia, or low blood sugar. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Let your doctor know if you experience hypoglycemia during treatment. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Coadministration of a glucagon-like peptide-1 (GLP-1) receptor agonist with insulin may potentiate the risk of hypoglycemia. GLP-1 receptor agonists lower blood glucose by stimulating insulin secretion and lowering glucagon secretion.

MANAGEMENT: When a GLP-1 receptor agonist is used as add-on therapy to basal insulin, a lower dosage of insulin may be required. Blood glucose should be monitored closely, and patients should be counseled to recognize the symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately and contact their physician. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery. Concurrent use of GLP-1 receptor agonists with prandial insulin has not been studied and is generally not recommended.

References
  • "Product Information. Ozempic (1 mg dose) (semaglutide)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
  • "Product Information. Adlyxin (lixisenatide)." sanofi-aventis, Bridgewater, NJ.
  • "Product Information. Trulicity (dulaglutide)." Eli Lilly and Company, Indianapolis, IN.
  • "Product Information. Victoza (liraglutide)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
  • "Product Information. Tanzeum (albiglutide)." GlaxoSmithKline, Research Triangle Park, NC.
  • "Product Information. Byetta (exenatide)." Amylin Pharmaceuticals Inc, San Diego, CA.
Bydureon Pen

Generic Name: exenatide

Brand name: Bydureon, Bydureon BCise, Bydureon Pen, Bydureon Tray, Byetta Prefilled Pen

Synonyms: Bydureon

ReliOn/Novolin 70/30

Generic Name: insulin isophane / insulin regular

Brand name: Humulin 70/30, HumuLIN 70/30 KwikPen, Novolin 70/30, ReliOn/Novolin 70/30, Humulin 50/50, Novolin 70/30, Humulin 50/50, Insulin Pork Mix, HumuLIN 70/30 Pen, NovoLIN 70/30 Innolet, NovoLIN 70/30 PenFill, Relion NovoLIN 70/30 Innolet, NovoLIN 70/30 FlexPen, ReliOn/NovLIN 70/30 FlexPen

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction