C1-Esterase Inhibitor (Recombinant) and Etanercept

• Generic Name: C1 esterase inhibitor (human)
• Dosage Forms: n.a.
• Other Brand Names: Berinert, Cinryze, Haegarda, Ruconest

Treatment of acute angioedema attacks in patients with hereditary angioedema (HAE). Designated an orphan drug by FDA for this use.

Clinical studies were conducted principally in patients with abdominal, facial, or peripheral angioedema; efficacy in patients with laryngeal HAE attacks not established.

Recommended by US and international consensus guidelines as one of several options for treatment of acute HAE attacks; other drugs include ecallantide (plasma kallikrein inhibitor) and icatibant (bradykinin B2-receptor antagonist).

• Generic Name: etanercept
• Dosage Forms: n.a.
• Other Brand Names: Enbrel, Erelzi Prefilled Syringe, Erelzi Sensoready Pen, Enbrel SureClick, Enbrel Prefilled Syringe, Enbrel Mini Prefilled Cartridge

Etanercept is a tumor necrosis factor (TNF) blocker that is used to treat:

• rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, and to prevent joint damage caused by these conditions;

• polyarticular juvenile idiopathic arthritis in children who are at least 2 years old; and

• plaque psoriasis in adults and children who are at least 4 years old.

Etanercept may also be used for purposes not listed in this medication guide.