C1-Esterase Inhibitor (Recombinant) and Hylenex Recombinant

• Generic Name: C1 esterase inhibitor (human)
• Dosage Forms: n.a.
• Other Brand Names: Berinert, Cinryze, Haegarda, Ruconest

Treatment of acute angioedema attacks in patients with hereditary angioedema (HAE). Designated an orphan drug by FDA for this use.

Clinical studies were conducted principally in patients with abdominal, facial, or peripheral angioedema; efficacy in patients with laryngeal HAE attacks not established.

Recommended by US and international consensus guidelines as one of several options for treatment of acute HAE attacks; other drugs include ecallantide (plasma kallikrein inhibitor) and icatibant (bradykinin B2-receptor antagonist).

• Generic Name: hyaluronidase
• Dosage Forms: injection, solution
• Other Brand Names: Amphadase, Hylenex, Vitrase, Wydase, Hydase

Hyaluronidase is a genetically designed protein.

Hyaluronidase is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications.

Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Hyaluronidase may also be used for purposes not listed in this medication guide.