C1-Esterase Inhibitor (Recombinant) and Phenergan VC

• Generic Name: C1 esterase inhibitor (human)
• Dosage Forms: n.a.
• Other Brand Names: Berinert, Cinryze, Haegarda, Ruconest

Treatment of acute angioedema attacks in patients with hereditary angioedema (HAE). Designated an orphan drug by FDA for this use.

Clinical studies were conducted principally in patients with abdominal, facial, or peripheral angioedema; efficacy in patients with laryngeal HAE attacks not established.

Recommended by US and international consensus guidelines as one of several options for treatment of acute HAE attacks; other drugs include ecallantide (plasma kallikrein inhibitor) and icatibant (bradykinin B2-receptor antagonist).

• Generic Name: phenylephrine / promethazine
• Dosage Forms: n.a.
• Other Brand Names: Phenergan VC, Promethazine VC Plain, Promethazine VC

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Promethazine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenergan VC is a combination medicine used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Phenergan VC may also be used for purposes not listed in this medication guide.