C-Topical and Zyvox (Linezolid Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cocaine topical together with linezolid can cause blood pressure to get dangerously high, which may be a medical emergency. Symptoms can include severe headache, palpitation, and chest pain or tightness. In general, it is recommended to avoid using medications or substances like cocaine topical until at least 2 weeks after stopping linezolid. Otherwise, blood pressure and heart rate should be closely monitored. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Cocaine exerts an indirect sympathomimetic effect and may precipitate hypertensive reactions and hyperpyrexia in patients treated with monoamine oxidase inhibitors (MAOIs), as has been reported with other indirect- or mixed-acting sympathomimetic agents such as amphetamine and ephedrine. The mechanism involves a synergistic effect due to enhanced norepinephrine storage in adrenergic neurons (MAOI activity) and decreased reuptake of catecholamines (indirect sympathomimetic activity). Headache, blood pressure increases, palpitations, and chest tightness were reported in two patients who used cocaine while receiving phenelzine for cocaine addiction. Increased serotonergic activity may also occur. An interaction resulting in unconsciousness, tremors, and muscle rigidity was suspected in a patient on phenelzine therapy who received 1 mL of a 10% cocaine spray to his vocal chords prior to surgery.

MANAGEMENT: In general, indirect-acting sympathomimetic agents such as cocaine should not be used concurrently with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with sympathomimetic agents.

C-Topical

Generic Name: cocaine topical

Brand name: C-Topical, Goprelto

Synonyms: C-Topical Solution

What is C-Topical?

Zyvox (Linezolid Suspension)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

What is Zyvox (Linezolid Suspension)?