Cablivi and Eculizumab

• Generic Name: caplacizumab
• Dosage Forms: injection
• Other Brand Names: Cablivi

Cablivi is used to treat acquired thrombotic thrombocytopenic purpura (aTTP) in adults. This medicine is given together with immunosuppressant medication and plasma exchange (transfusion).

Cablivi may also be used for purposes not listed in this medication guide.

• Generic Name: eculizumab
• Dosage Forms: n.a.
• Other Brand Names: Soliris

Eculizumab is a monoclonal antibody. Eculizumab binds to proteins in the blood that can destroy red blood cells in people with genetic conditions that affect the natural defenses of red blood cells.

Eculizumab is used to prevent the breakdown of red blood cells in adults with paroxysmal nocturnal hemoglobinuria (PNH).

Eculizumab is also used to treat a rare chronic blood disease called atypical hemolytic uremic syndrome (aHUS) in adults and children who weigh at least 11 pounds (5 kilograms).

Eculizumab is also used to treat myasthenia gravis in adults.

Eculizumab is also used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults.

Eculizumab is available only under a special program. You must be registered in the program and understand the risks and benefits of eculizumab.

Eculizumab may also be used for purposes not listed in this medication guide.