Cabozantinib Capsules and Metformin and sitagliptin
Determining the interaction of Cabozantinib Capsules and Metformin and sitagliptin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Cabozantinib may increase the blood levels and effects of SITagliptin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro inhibition data, coadministration with cabozantinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by cabozantinib.
MANAGEMENT: Caution is advised when cabozantinib is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever cabozantinib is added to or withdrawn from therapy.
- "Product Information. Cometriq (cabozantinib)." Exelixis Inc, S San Francisco, CA.
Generic Name: cabozantinib
Brand name: Cabometyx, Cometriq
Synonyms: Cabozantinib
Generic Name: metformin / sitagliptin
Brand name: Janumet, Janumet XR
Synonyms: Sitagliptin and Metformin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cabozantinib Capsules-Metformin Extended-Release Tablets
- Cabozantinib Capsules-Metformin Hydrochloride
- Cabozantinib Capsules-Metformin Oral Solution
- Cabozantinib Capsules-Metformin Tablets
- Cabozantinib Capsules-Methacholine
- Cabozantinib Capsules-Methadone
- Metformin and sitagliptin-Cabozantinib S-malate
- Metformin and sitagliptin-Cabozantinib Tablets
- Metformin and sitagliptin-Caduet
- Metformin and sitagliptin-Cafcit
- Metformin and sitagliptin-Cafcit (Caffeine Citrate Injection Solution)
- Metformin and sitagliptin-Cafcit (Caffeine Citrate Oral Solution)