Cabozantinib Tablets and Oxtellar XR
Determining the interaction of Cabozantinib Tablets and Oxtellar XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:OXcarbazepine may reduce the blood levels of cabozantinib in some patients, which may make the medication less effective. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of cabozantinib, which is a substrate of the isoenzyme. In healthy subjects, administration of the potent CYP450 3A4 inducer rifampin (600 mg daily for 31 days) decreased single-dose cabozantinib plasma exposure (AUC) by 77%. The extent to which other, less potent CYP450 3A4 inducers may interact with cabozantinib is unknown.
MANAGEMENT: The potential for diminished pharmacologic effects of cabozantinib should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.
- "Product Information. Cometriq (cabozantinib)." Exelixis Inc, S San Francisco, CA.
- "Product Information. Cabometyx (cabozantinib)." Exelixis Inc, S San Francisco, CA.
Generic Name: cabozantinib
Brand name: Cabometyx, Cometriq
Synonyms: Cabozantinib
Generic Name: oxcarbazepine
Brand name: Oxtellar XR, Trileptal
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cabozantinib Tablets-Oxtriphylline and guaifenesin
- Cabozantinib Tablets-Oxy Balance Topical
- Cabozantinib Tablets-Oxy Daily Wash
- Cabozantinib Tablets-Oxy-10
- Cabozantinib Tablets-Oxybutynin
- Cabozantinib Tablets-Oxybutynin Chloride
- Oxtellar XR-Caduet
- Oxtellar XR-Cafcit
- Oxtellar XR-Cafcit (Caffeine Citrate Injection Solution)
- Oxtellar XR-Cafcit (Caffeine Citrate Oral Solution)
- Oxtellar XR-Cafcit Intravenous
- Oxtellar XR-Cafcit Oral