Cafergot (Ergotamine and Caffeine Suppositories) and Topotecan Hydrochloride
Determining the interaction of Cafergot (Ergotamine and Caffeine Suppositories) and Topotecan Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.
- Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res 53 (1993): 4613-8
Generic Name: caffeine / ergotamine
Brand name: Cafergot, Migergot, Wigraine, Cafetrate, Ercaf, Cafatine
Synonyms: Cafergot (Suppositories), Cafergot
Generic Name: topotecan
Brand name: Hycamtin
Synonyms: Topotecan (oral/injection), Topotecan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cafergot (Ergotamine and Caffeine Suppositories)-Topotecan Injection
- Cafergot (Ergotamine and Caffeine Suppositories)-Topotecan Injection, Concentrate
- Cafergot (Ergotamine and Caffeine Suppositories)-Topotecan Intravenous
- Cafergot (Ergotamine and Caffeine Suppositories)-Topotecan oral/injection
- Cafergot (Ergotamine and Caffeine Suppositories)-Toprol XL
- Cafergot (Ergotamine and Caffeine Suppositories)-Topsyn
- Topotecan Hydrochloride-Cafergot (Ergotamine and Caffeine Tablets)
- Topotecan Hydrochloride-Cafergot Tablets
- Topotecan Hydrochloride-Caffeine
- Topotecan Hydrochloride-Caffeine and ergotamine oral/rectal
- Topotecan Hydrochloride-Caffeine and sodium benzoate Injection
- Topotecan Hydrochloride-Caffeine Capsules and Tablets