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Cafergot (Ergotamine and Caffeine Tablets) and Darunavir Tablets

Determining the interaction of Cafergot (Ergotamine and Caffeine Tablets) and Darunavir Tablets and the possibility of their joint administration.

Check result:
Cafergot (Ergotamine and Caffeine Tablets) <> Darunavir Tablets
Relevance: 17.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ergotamine together with darunavir is not recommended. Combining these medications may significantly increase the blood levels and effects of ergotamine, which in some cases can lead to excessive narrowing of blood vessels in the body. This can reduce blood flow to vital organs and increase the risk of rare but serious side effects such as high blood pressure, heart attack, stroke, and gangrene (death of tissues, usually in the arm or leg, that may require surgical amputation). You should seek immediate medical attention if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech during treatment with ergotamine. Do not take larger doses or use the drug more frequently than prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with protease inhibitors (PIs), particularly ritonavir, may significantly increase the plasma concentrations of ergot derivatives. The mechanism is PI inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of ergotamine and related drugs. Clinical ergotism, occasionally resulting in surgical amputation or death, has been reported in patients receiving ergotamine tartrate with ritonavir, indinavir, and/or nelfinavir. Even small, single doses of ergotamine have been involved in clinically significant interactions.

MANAGEMENT: Given the potential for ergot toxicity characterized by peripheral vasospasm, ischemia, thrombosis, tachycardia and hypertension, concomitant use of ergot derivatives with protease inhibitors is considered contraindicated.

References
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Cafergot (Ergotamine and Caffeine Tablets)

Generic Name: caffeine / ergotamine

Brand name: Cafergot, Migergot, Wigraine, Cafetrate, Ercaf, Cafatine

Synonyms: Cafergot (Suppositories), Cafergot

What is Cafergot (Ergotamine and Caffeine Tablets)?
Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?
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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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