Caffeine and ergotamine oral/rectal and Hycamtin
Determining the interaction of Caffeine and ergotamine oral/rectal and Hycamtin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.
- Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res 53 (1993): 4613-8
Generic Name: caffeine / ergotamine
Brand name: Cafergot, Migergot, Wigraine, Cafetrate, Ercaf, Cafatine
Synonyms: Caffeine and ergotamine (oral/rectal), Ergotamine and Caffeine
Generic Name: topotecan
Brand name: Hycamtin
Synonyms: Hycamtin (oral/injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Caffeine and ergotamine oral/rectal-Hycamtin (Topotecan Capsules)
- Caffeine and ergotamine oral/rectal-Hycamtin (Topotecan Injection)
- Caffeine and ergotamine oral/rectal-Hycamtin Capsules
- Caffeine and ergotamine oral/rectal-Hycamtin Intravenous
- Caffeine and ergotamine oral/rectal-Hycamtin oral/injection
- Caffeine and ergotamine oral/rectal-Hycet
- Hycamtin-Caffeine and sodium benzoate Injection
- Hycamtin-Caffeine Capsules and Tablets
- Hycamtin-Caffeine Citrate
- Hycamtin-Caffeine Citrate Injection Solution
- Hycamtin-Caffeine citrate Intravenous
- Hycamtin-Caffeine Citrate Oral Solution