Caffeine and ergotamine oral/rectal and ONZETRA Xsail
Determining the interaction of Caffeine and ergotamine oral/rectal and ONZETRA Xsail and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using SUMAtriptan together with ergotamine is not recommended. Combining these medications may have additive effects and cause excessive narrowing of blood vessels in the body. This can reduce blood flow to vital organs and increase the risk of rare but serious side effects such as high blood pressure, heart attack, stroke, and gangrene (death of tissues, usually in the arm or leg, that may require surgical amputation). You should seek immediate medical attention if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech during treatment with these medications. Do not take larger doses or use the drug more frequently than prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration of two or more 5-HT1 receptor agonists and/or ergotamine-containing or ergot-type medications may potentiate the risk of vasospastic reactions, including coronary artery vasospasm, peripheral vascular ischemia and colonic ischemia, due to additive pharmacologic effects. Acute myocardial infarction due to sustained vasospasm occurred in a premenopausal woman with controlled hypertension and no known history of coronary artery disease following two 2 mg doses of methysergide maleate 12 hours apart and a subcutaneous injection of sumatriptan 6 mg.
MANAGEMENT: The concomitant use of two or more 5-HT1 receptor agonists and/or ergotamine-containing or ergot-type medications, or use within 24 hours of each other, is considered contraindicated.
- "Product Information. Parlodel (bromocriptine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Axert (almotriptan)" Pharmacia and Upjohn, Kalamazoo, MI.
- Liston H, Bennett L, Usher B, Nappi J "The association of the combination of sumatriptan and methysergide in myocardial infarction in a premenopausal woman." Arch Intern Med 159 (1999): 511-3
- "Product Information. Imitrex (sumatriptan)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Migranal (dihydroergotamine nasal)." Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. Zomig (zolmitriptan)." Zeneca Pharmaceuticals, Wilmington, DE.
- "Product Information. Maxalt (rizatriptan)." Merck & Co, Inc, West Point, PA.
- "Product Information. Relpax (eletriptan)." Pfizer U.S. Pharmaceuticals, New York, NY.
- "Product Information. Amerge (naratriptan)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: caffeine / ergotamine
Brand name: Cafergot, Migergot, Wigraine, Cafetrate, Ercaf, Cafatine
Synonyms: Caffeine and ergotamine (oral/rectal), Ergotamine and Caffeine
Generic Name: sumatriptan
Brand name: ONZETRA Xsail, Alsuma, Imitrex, Imitrex STATdose, Imitrex Statdose Refill, Sumavel DosePro, Zembrace SymTouch, SUMAtriptan Succinate Syringe, Imitrex<, Tosymra, Zecuity
Synonyms: Onzetra Xsail
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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