Caffeine and sodium benzoate Injection and Clozapine Oral Suspension
Determining the interaction of Caffeine and sodium benzoate Injection and Clozapine Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Caffeine may increase clozapine serum concentrations and exacerbate psychotic symptoms. The mechanism is unknown but may be related to competition for the same metabolic pathway. No specific intervention is necessary; however, if an interaction is suspected it is recommended that caffeine intake be avoided.
- Hagg S, Spiset O, Mjorndal T, Dalqvist R "Effect of caffeine on clozapine pharmacokinetics in healthy volunteers." Br J Clin Pharmacol 49 (2000): 59-63
- Odom-White A, de Leon J "Clozapine levels and caffeine." J Clin Psychiatry 57 (1996): 175-6
- Vainer JL, Chouinard G "Interaction between caffeine and clozapine." J Clin Psychopharmacol 14 (1994): 284
- Carrillo JA, Jerling M, Bertilsson L "Interaction between caffeine and clozapine - comment." J Clin Psychopharmacol 15 (1995): 376-7
Generic Name: caffeine / sodium benzoate
Brand name: Cafcit, No Doz, Vivarin
Synonyms: Caffeine and sodium benzoate (Injection)
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: Clozapine, CloZAPine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Caffeine and sodium benzoate Injection-Clozapine Orally Disintegrating Tablet
- Caffeine and sodium benzoate Injection-Clozapine Orally Disintegrating Tablets
- Caffeine and sodium benzoate Injection-Clozapine Tablets
- Caffeine and sodium benzoate Injection-Clozaril
- Caffeine and sodium benzoate Injection-CNJ-016 Injection
- Caffeine and sodium benzoate Injection-Co-Gesic
- Clozapine Oral Suspension-Caffeine Capsules and Tablets
- Clozapine Oral Suspension-Caffeine Citrate
- Clozapine Oral Suspension-Caffeine Citrate Injection Solution
- Clozapine Oral Suspension-Caffeine citrate Intravenous
- Clozapine Oral Suspension-Caffeine Citrate Oral Solution
- Clozapine Oral Suspension-Caffeine; Caffeine and Sodium Benzoate Injection; Caffeine Citrate