Cal-Mint and Divalproex Long-Acting Tablets
Determining the interaction of Cal-Mint and Divalproex Long-Acting Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that concurrent administration of antacids may increase the bioavailability of valproic acid. The mechanism of interaction is unknown. In seven healthy volunteers, coadministration of a single 500 mg dose of valproic acid one hour after breakfast and an antacid containing aluminum-magnesium hydroxide (dose equal to 160 mEq of neutralizing capacity) one and three hours after meals and at bedtime on the same day resulted in a mean 12% increase (range 3% to 28%) in the total area under the concentration-time curve (AUC) of valproic acid compared to administration alone. These changes are unlikely to be of clinical importance, and no special precautions appear to be necessary. Equivalent doses of antacids containing either aluminum hydroxide-magnesium trisilicate or calcium carbonate also increased the AUC of valproic acid, but the differences were not statistically significant.
- "Product Information. Depakote (divalproex sodium)." Abbott Pharmaceutical, Abbott Park, IL.
- May CA, Garnett WR, Small RE, Pellock JM "Effects of three antacids on the bioavailability of valproic acid." Clin Pharm 1 (1982): 244-7
Generic Name: calcium carbonate
Brand name: Cal-Mint, Calci-Chew, Oysco 500, Calci Mix, Os-Cal 500, Oyst Cal 500, Oyster Shell Calcium 500, Nephro Calci, Amitone, Dicarbosil, Equilet, Tums, Chooz, Tums E-X, Alkets, Titralac, Oyster Cal 500, Calcitab, Oyster Shell, Oyster Calcium, Super Calcium, Calcium Concentrate, Caltro, Oyster, Oyster Cal, Cal Oys, Alkums, Cal-Gest, Tums 500, Tums Ultra, Alka-Mints, Calcarb, Caltrate, Rolaids Sodium Free, Amilac, Calcium Oyster, Oyst Cal, Calcium Liquid Softgel, Mylanta Child, Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Ultra Mylanta Calci Tabs, Extra Strength Mylanta Calci Tabs, Os-Cal, Surpass, Surpass Extra Strength, Icar Prenatal Chewable Calcium, Tums Extra Strength, Maalox Quick Dissolve Extra Strength, Calcium Oyster Shell, Maalox Antacid Barrier, Rolaids Soft Chew, Pepto Children's, Maalox Regular Strength, Maalox Children's, Tums Kids, Tums QuikPak, Calci-Mix, Alcalak, Tums Smoothies, Tums Chewy Bites, Tums Chewy Delights, Tums Sugar-Free, Calci Mix, OsCal 500
Synonyms: n.a.
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon
Synonyms: Divalproex sodium, Divalproex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cal-Mint-Divalproex sodium
- Cal-Mint-Divalproex Sprinkle
- Cal-Mint-Divalproex Sprinkle Capsules
- Cal-Mint-Divigel
- Cal-Mint-Divigel 0.75 mg/packet for use on skin
- Cal-Mint-Divigel Transdermal
- Divalproex Long-Acting Tablets-Calan
- Divalproex Long-Acting Tablets-Calan (Verapamil Immediate-Release Tablets)
- Divalproex Long-Acting Tablets-Calan (Verapamil Injection)
- Divalproex Long-Acting Tablets-Calan SR
- Divalproex Long-Acting Tablets-Calaspargase Pegol
- Divalproex Long-Acting Tablets-Calaspargase Pegol-mknl