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Calan SR and Vincristine Intravenous

Determining the interaction of Calan SR and Vincristine Intravenous and the possibility of their joint administration.

Check result:

Calan SR <> Vincristine Intravenous

Relevance: 16.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro tests have shown that verapamil displaces vincristine from protein-binding sites--particularly alpha(1) -acid glycoprotein, or AGP. The clinical significance is unknown. If verapamil and vincristine are used concomitantly, close neurological observation is advised.

References

Abdel-Rahman M, Wosch F, Harder S, Woodcock BG "Interaction between verapamil and vincristine binding to plasma proteins." Int J Clin Pharmacol Ther Toxicol 30 (1992): 536-7

Calan SR

Generic Name: verapamil

Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: n.a.

What is Calan SR?

Vincristine Intravenous

Generic Name: vincristine

Brand name: Oncovin, Vincasar PFS

Synonyms: Vincristine, VinCRIStine

What is Vincristine Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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