Calcitriol (Systemic) and Sevelamer Powder Packets
Determining the interaction of Calcitriol (Systemic) and Sevelamer Powder Packets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sevelamer together with calcitriol may decrease the effects of calcitriol. Calcitriol should be administered at least 4 hours before sevelamer. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).
MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.
- Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: calcitriol
Brand name: Calcijex, Rocaltrol
Synonyms: Calcitriol
Generic Name: sevelamer
Brand name: Renagel, Renvela
Synonyms: Sevelamer
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Calcitriol (Systemic)-Sevelamer Suspension
- Calcitriol (Systemic)-Sevelamer Tablets
- Calcitriol (Systemic)-Severent
- Calcitriol (Systemic)-Severent Diskhaler
- Calcitriol (Systemic)-Severent Diskus
- Calcitriol (Systemic)-Sevoflurane
- Sevelamer Powder Packets-Calcitriol Capsules
- Sevelamer Powder Packets-Calcitriol Injection
- Sevelamer Powder Packets-Calcitriol Injection Solution
- Sevelamer Powder Packets-Calcitriol Ointment
- Sevelamer Powder Packets-Calcitriol Oral Solution
- Sevelamer Powder Packets-Calcitriol topical