Calcium Carbonate and Simethicone and Hydrocortisone Rectal Suspension
Determining the interaction of Calcium Carbonate and Simethicone and Hydrocortisone Rectal Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Antacids and agents with acid-neutralizing effects may impair the absorption of dexamethasone, prednisolone, prednisone, and other corticosteroids, although data from published studies are somewhat conflicting. The mechanism of interaction and clinical significance are unknown. No particular intervention is necessary during concomitant therapy with these agents, but clinicians should be aware of the potential for interaction.
- Naggar VF, Khalil SA, Gouda MW "Effect of concomitant administration of magnesium trisilicate on GI absorption of dexamethasone in humans." J Pharm Sci 67 (1978): 1029-30
- Tanner AR, Caffin JA, Halliday JW, Powell LW "Concurrent administration of antacids and prednisone: effect on serum levels of prednisolone." Br J Clin Pharmacol 7 (1979): 397-400
- Albin H, Vincon G, Demotes-Mainard F, et al "Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone." Eur J Clin Pharmacol 26 (1984): 271-3
Generic Name: calcium carbonate / simethicone
Brand name: Alka-Seltzer Heartburn + Gas, Gas-X with Maalox Extra Strength, Maalox Advanced Maximum Strength, Maalox Junior Plus Antigas, Tums Gas Relief Chewy Bites
Synonyms: n.a.
Generic Name: hydrocortisone
Brand name: Cortef, Colocort, Cortenema, Cortifoam, Solu-Cortef
Synonyms: Hydrocortisone, Hydrocortisone (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Calcium Carbonate and Simethicone-Hydrocortisone Sodium Phosphate
- Calcium Carbonate and Simethicone-Hydrocortisone Sodium Succinate
- Calcium Carbonate and Simethicone-Hydrocortisone Suppository
- Calcium Carbonate and Simethicone-Hydrocortisone Tablets
- Calcium Carbonate and Simethicone-Hydrocortisone topical
- Calcium Carbonate and Simethicone-Hydrocortisone Topical application
- Hydrocortisone Rectal Suspension-Calcium Carbonate Capsules and Tablets
- Hydrocortisone Rectal Suspension-Calcium Carbonate Chewable Tablets
- Hydrocortisone Rectal Suspension-Calcium Carbonate Chewable Tablets (Antacid)
- Hydrocortisone Rectal Suspension-Calcium Carbonate Suspension
- Hydrocortisone Rectal Suspension-Calcium Carbonate Tablets (Antacid)
- Hydrocortisone Rectal Suspension-Calcium carbonate, magnesium hydroxide, and simethicone