Calcium carbonate, magnesium hydroxide, and simethicone and Valproic Acid and Derivatives
Determining the interaction of Calcium carbonate, magnesium hydroxide, and simethicone and Valproic Acid and Derivatives and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that concurrent administration of antacids may increase the bioavailability of valproic acid. The mechanism of interaction is unknown. In seven healthy volunteers, coadministration of a single 500 mg dose of valproic acid one hour after breakfast and an antacid containing aluminum-magnesium hydroxide (dose equal to 160 mEq of neutralizing capacity) one and three hours after meals and at bedtime on the same day resulted in a mean 12% increase (range 3% to 28%) in the total area under the concentration-time curve (AUC) of valproic acid compared to administration alone. These changes are unlikely to be of clinical importance, and no special precautions appear to be necessary. Equivalent doses of antacids containing either aluminum hydroxide-magnesium trisilicate or calcium carbonate also increased the AUC of valproic acid, but the differences were not statistically significant.
- "Product Information. Depakote (divalproex sodium)." Abbott Pharmaceutical, Abbott Park, IL.
- May CA, Garnett WR, Small RE, Pellock JM "Effects of three antacids on the bioavailability of valproic acid." Clin Pharm 1 (1982): 244-7
Generic Name: calcium carbonate / magnesium hydroxide / simethicone
Brand name: Mylanta Tonight
Synonyms: n.a.
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Calcium carbonate, magnesium hydroxide, and simethicone-Valproic Acid Capsules
- Calcium carbonate, magnesium hydroxide, and simethicone-Valproic Acid Liquid
- Calcium carbonate, magnesium hydroxide, and simethicone-Valproic Acid Oral Solution
- Calcium carbonate, magnesium hydroxide, and simethicone-Valproic Acid Syrup
- Calcium carbonate, magnesium hydroxide, and simethicone-Valrubicin
- Calcium carbonate, magnesium hydroxide, and simethicone-Valrubicin Intravesical
- Valproic Acid and Derivatives-Calcium Carbonate/Vit D/Vit B6/Vit B12/Folic Acid with Minerals Chew Wafers
- Valproic Acid and Derivatives-Calcium Chloride
- Valproic Acid and Derivatives-Calcium citrate
- Valproic Acid and Derivatives-Calcium Disodium Versenate
- Valproic Acid and Derivatives-Calcium Folinate Injection
- Valproic Acid and Derivatives-Calcium Glubionate